Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination
Resource
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 45 (35),5822-5825
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 45
Pages
5822-5825
Date Issued
2006-04
Date
2006-04
Author(s)
CHEN, PO-LIANG
HSIAO, CHIH-HSIEN
CHEN, JIANN-TORNG
LU, DA-WEN
CHEN, WIN-YING
DOI
246246/2006111501264909
Abstract
PURPOSE: To evaluate the efficacy and safety of apraclonidine
0.5% in the diagnosis of Horner syndrome in
pediatric patients.
DESIGN: Prospective, interventional case series.
METHODS: Ten pediatric patients with a diagnosis of
Horner syndrome and 10 age-matched controls with
physiologic anisocoria underwent pharmacological testing
with apraclonidine. The difference between the pupil
diameters of both eyes under low (room light off) and
high (room light on) ambient illumination before and one
hour after apraclonidine was instilled was recorded. Any
adverse effects during the examination or reported by the
patient’s parents were recorded.
RESULTS: The mean differences in pupil diameters
before and after apraclonidine testing in the Horner
syndrome group were 2.05 mm and 0.97 mm, respectively,
under low illumination (P .0049) and 1.48
mm and 1.1 mm, respectively, under high illumination
(P .0051). Three patients with Horner syndrome
showed positive values (reversal of anisocoria) only
under high ambient illumination, but not under low
illumination. There was no statistical difference in the
mean differences in pupil diameter before and after
apraclonidine testing in the control group. Conjunctival
hyperemia was noted in two patients with Horner syndrome
and in three patients in the control group. No
systemic adverse effects were noted during the examination
or were reported by patients’ parents.
CONCLUSIONS: The application of apraclonidine in
pediatric patients is safe and effective in the diagnosis of
Horner syndrome. The reversal of anisocoria was more
obvious under high (room light on) ambient illumination.
Subjects
charge transfer
conjugation
dyes/pigments
photosensitizers
ruthenium
Publisher
Taipei:National Taiwan University Dept Chem Engn
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
335.pdf
Size
22.97 KB
Format
Adobe PDF
Checksum
(MD5):336d417391a731f20f004f5579679e3e