Linkage of Schizophrenia with Chromosome 1q Loci in Taiwanese Families
Resource
MOLECULAR PSYCHIATRY v.8 n.4 pp.445-452
Journal
MOLECULAR PSYCHIATRY
Journal Volume
v.8
Journal Issue
n.4
Pages
445-452
Date Issued
2003
Date
2003
Author(s)
Hwu, H-G
Liu, C-M
Fann, C S-J
Ou-Yang, W-C
Lee, S F-C
Abstract
A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22-44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q 2231 (17.8cM ), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype ( DSM-IV schizophrenia only). In the region 1q42-44 (26.8cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q 14.3) segregated with schizophrenia, and also near the neurodevelopment- related'Disrupted in Schizophrenia 1' gene, had a maximum NPL score of 1. 73 (P=0.03) under the narrow phenotype model and 2.18(P = 0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder , and other nonaffective psychotic disorders as defined by DSM-IV criteria . The marker D1S2836 also had a maximal proportion ( 0.57, P = 0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22-31 and 1q41-44 regions.
Subjects
POTASSIUM CHANNEL GENE
MULTIPLE SUSCEPTIBILITY LOCI
GENOME- WIDE SEARCH
DUFFY BLOOD-GROUP
BIPOLAR DISORDER
CAG REPEAT