Chemical investigation on the root bark of Bombax malabarica
Journal
Fitoterapia
Journal Volume
139
Pages
104376
Date Issued
2019
Author(s)
Abstract
Ten compounds were isolated from the root bark of Bombax malabarica, including two new compounds, bombamalin (1) and 3,4,5-trimethoxyphenol-1-[β-xylopyranosyl-(1 → 2)]-β-glucopyranoside (3), and shorealactone (4), a rare dehydroascorbic acid fused l-ε-viniferin. Compound 1 is an unusual bissesquiterpene, containing a 1,4-dioxene ring formed by fusing isohemigossypol with ent-cadinen-2-one. Their structures were elucidated by extensive spectroscopic analysis. This chemical reinvestigation is of value for chemotaxonomy of the Bombax genus, in particular the finding of the unusual 1 and rare 4. Among the isolates, shorealactone (4), l-epicatechin 5-O-β-D-xyloside (5), and 2-C-[β-D-apiosyl-(1 → 6)]- β-D-glucosyl]-1,3,6-trihydroxy-7-methoxyxanthone (6) displayed some inhibition against α-glucosidase with IC50 values of 224, 345, and 285 μM, respectively.
Type
journal article