聚乙烯醇薄膜應用於人工胰臟的動物實驗

Our previous in vitro studies have
demonstrated that poly (vinyl alcohol) (PVA)
membranes satisfy the basic requirements for
a bioartificial pancreas. This experiment was
designed to evaluate the performance of m-1
and m-2 tubular membrane chambers
containing islets in vivo. When the m-2
chamber was implanted into streptozotocin
(STZ)-induced diabetic rats, nonfasting blood
glucose levels dropped from 500±35 to the
lowest value 210±22 mg/dl. Furthermore, the
performance of the bioartificial pancreas can
be enhanced by the increased numbers of
implanted chambers. If three m-2 chambers
was implanted, nonfasting blood glucose
levels in the diabetic rats decreased to 130-160
mg/dl and such a low blood glucose
value was maintained for 1 month. In
addition, a mathematical kinetic model was
developed to describe the characteristics of islet inside an artificial environment.