Two new cytotoxic clerodane diterpenoids from Casearia membranacea
Journal
Chemical and Pharmaceutical Bulletin
Journal Volume
52
Journal Issue
1
Pages
108-110
Date Issued
2004
Author(s)
Abstract
In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells. ? 2004 Pharmaceutical Society of Japan.
Subjects
Casearia membranacea; Clerodanes; Cytotoxicity; Flacourtiaceae
SDGs
Other Subjects
caseamembrol a; caseamembrol b; casearlucin a; clerodane derivative; diterpene; plant extract; unclassified drug; alcohol; antineoplastic agent; caseamembrol A; caseamembrol B; clerodane derivative; diterpene; solvent; antineoplastic activity; article; bioassay; cancer cell; Casearia; Casearia membranacea; controlled study; cytotoxicity; drug isolation; drug structure; fractionation; human; human cell; nonhuman; nuclear magnetic resonance spectroscopy; plant leaf; prostate cancer; structure analysis; Casearia; chemistry; conformation; fast atom bombardment mass spectrometry; isolation and purification; male; pathology; plant stem; prostate tumor; thin layer chromatography; tumor cell line; ultraviolet spectrophotometry; Antineoplastic Agents, Phytogenic; Casearia; Cell Line, Tumor; Chromatography, Thin Layer; Diterpenes; Diterpenes, Clerodane; Ethanol; Humans; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Plant Leaves; Plant Stems; Prostatic Neoplasms; Solvents; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet
Type
journal article