Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Engineering / 工學院
  3. Chemical Engineering / 化學工程學系
  4. Synthesis of Temperature Sensitive Copolymers In Supercritical Carbon Dioxide
 
  • Details

Synthesis of Temperature Sensitive Copolymers In Supercritical Carbon Dioxide

Date Issued
2010
Date
2010
Author(s)
Huang, Siou-Huei
URI
http://ntur.lib.ntu.edu.tw//handle/246246/252419
Abstract
In recent years, the intelligent materials with biodegradable have been employed in research and development for the drug delivery and biological processes. Supercritical fluid technology has the advantages of reducing significantly the amount of solvent in traditional process. It can also avoid the oxidation of initiators, and simplify the following separation steps. In this research we synthesize the temperature sensitive materials by using the supercritical carbon dioxide to protect the environment. Poly(N-isopropylacylamide), PNIPAAm, is a thermoresponsive polymer that has lower critical solution temperature(LCST) around 31~32 ℃ in aqueous solution. In this study, PNIPAAm copolymers with hydrophilic comonomers, Methacrylic acid (MAA) and N-Methyl-N-vinylacetamide (MVA), were synthesized in order to obtain copolymers with LCST slightly higher than the physiological temperature(37 ℃), as required by a drug delivery concept. The two copolymers, P(NIPAAm-co-MAA) and P(NIPAAm-co-MVA), were examined using FTIR to confirm their chemical structures. In UV analysis, we found that only the LCST of P(NIPAAm-co-MVA) could be promoted to around 37 ℃ in aqueous solution. However the LCST of P(NIPAAm-co-MAA) can be increased in base solution (pH=8.67). In TGA analysis, the thermal stability of copolymers can be observed. In SEM images, We observed that the particle size of two copolymers all became smaller by adding the crosslinkers, and the particle size of P(NIPAAm-co- MAA) can be reduced to 0.068µm by increasing the amount of MAA.
Subjects
supercritical carbon dioxide
temperature-sensitive
hydrophilic monomer
hydrogel
LCST
Type
thesis
File(s)
Loading...
Thumbnail Image
Name

ntu-99-R97524028-1.pdf

Size

23.53 KB

Format

Adobe PDF

Checksum

(MD5):c40864887a66c3bcb070836c451f6c01

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science