Prenatal diagnosis by transabdominal chorionic villus sampling in the second and third trimesters
Journal
Archives of Gynecology and Obstetrics
Journal Volume
256
Journal Issue
4
Pages
193-197
Date Issued
1995
Author(s)
Abstract
From October 1989 through December 1993, 124 pregnant women (114 in the second trimester and 10 in the third trimester) underwent transabdominal chorionic villus sampling (CVS) for prenatal molecular or cytogenetic diagnosis. The mean gestational age was 18.2 weeks. Indications for CVS comprised single gene disease (72%), fetal anomalies detected by ultrasound (17%), advanced maternal age (6%), and previous siblings with chromosomal aberration (5%). Among the 89 fetuses at risk for single gene disease, 20 were diagnosed as affected by DNA analysis. Among the 35 fetuses at risk for chromosomal anomaly, 4 had trisomy, 3 had a 45, XO karyotype and 2 had a structural chromosomal abnormality. The miscarriage rate was 1.8% (2/114) and the spontaneous preterm birth rate was 2.4% (3/124). No maternal or other fetal complications occurred. This study suggested that second- and third trimester CVS is a safe and useful method for prenatal diagnosis. ? 1995 Springer-Verlag.
SDGs
Other Subjects
adult; article; birth rate; chorion villus sampling; chromosome aberration; chromosome analysis; dna determination; female; fetus echography; fetus malformation; gestational age; human; human experiment; male; maternal age; monogenic disorder; normal human; prenatal diagnosis; second trimester pregnancy; sibling; spontaneous abortion; third trimester pregnancy; Abnormalities, Multiple; Chorionic Villi Sampling; Chromosome Aberrations; Chromosome Disorders; Female; Genetic Diseases, Inborn; Human; Infant, Newborn; Karyotyping; Male; Maternal Age 35 and over; Middle Age; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Risk Factors; Support, Non-U.S. Gov't
Type
journal article