探討GSTT1基因多型性與宜蘭地區砷暴露相關之糖尿病的關係
Date Issued
2004
Date
2004
Author(s)
曾慶孝
DOI
922320B002156
Abstract
This study evaluated the possible
association between diabetes mellitus and the
glutathione S-transferase (GST) T1 genotype
in residents of the Ilan county, who showed
history of arsenic exposure from drinking
well water. A total of 651 subjects were
studied. Among them, 76 were diabetic and
573 were not diabetic. GST T1 genotyping
was performed by a polymerase chain
reaction technique and the genotypes were
classified as null and non-null types. Results
showed that with comparable age, sex and
body mass index, GST T1 null type was
present in 58.3% of the non-diabetic subjects
and 46.2% of the diabetic patients (p<0.05),
suggesting an association between non-null
type GSTT1 and diabetes mellitus. Further
studies with larger sample size or studies
involving the metabolites of arsenic and the
detoxification procedures are required to
clarify the role of arsenic on the impact of
human health hazards.
Subjects
diabetes mellitus
environmental
pollutants
pollutants
arsenic
polymerase
chain reaction
chain reaction
molecular biology
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
922320B002156.pdf
Size
77.12 KB
Format
Adobe PDF
Checksum
(MD5):00e92132722ed517dc8bfe00c176824d