Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone
Journal
Aging Male
Journal Volume
19
Journal Issue
2
Pages
96-101
Date Issued
2016
Author(s)
Abstract
Abstract: Introduction: Testosterone deficiency increases the cardiovascular disease (CVD) risk. Aim: To evaluate the effect of erectile dysfunction (ED), sexual frequency and hypogonadal symptoms on CVD risk. Methods: A total of 395 hypogonadal men aged 45–74 years were surveyed using the Androgen Deficiency in the Aging Male and the International Index of Erectile Function. Main outcome measures: The 10-year CVD risk was measured with the Framingham Risk Score. Logistic regression was performed to obtain the odds ratios of sexual function and hypogonadal symptoms for a 10-year CVD risk ?20% (high risk). Results: The mean age was 56.1 ± 6.7 years. The mean 10-year CVD risk of the whole cohort was 18.1% ± 11.4%, while 131 subjects (33.2%) were classified as high risk. Logistic regression revealed that ED severity was associated with CVD risk [OR = 2.37 (CI 1.24–4.51) for mild-to-moderate ED, OR = 4.39 (1.78–8.43) for moderate ED and OR = 12.81 (4.65–26.11) for severe ED]. Compared to sexual frequency <1 per month, sexual frequency ?4 decreased the risk of high CVD risk [OR = 0.35 (0.23–0.780)]. Loss of libido [OR = 2.95 (1.91–4.12)] and less strong erection [OR = 3.87 (CI 2.11–4.95)] increased the risk of high CVD risk. All remained significant after adjustment for age and testosterone. Conclusions: ED, decreased sexual frequency and loss of libido predict a high 10-year CVD risk in hypogonadal men. ? 2016 Informa UK Limited, trading as Taylor & Francis Group.
SDGs
Other Subjects
testosterone; testosterone; adult; age; aged; Androgen Deficiency in the Aging Male; Article; cardiovascular risk; cohort analysis; diabetes mellitus; disease severity; erectile dysfunction; Framingham risk score; genital system disease assessment; health survey; human; hypertension; International Index of Erectile Function; libido disorder; major clinical study; male; metabolic syndrome X; middle aged; priority journal; sexual behavior; sexual frequency; sexual function; testosterone blood level; Cardiovascular Diseases; complication; deficiency; erectile dysfunction; eunuchoidism; libido; physiology; risk factor; sexual behavior; statistical model; Cardiovascular Diseases; Erectile Dysfunction; Eunuchism; Humans; Libido; Logistic Models; Male; Middle Aged; Risk Factors; Sexual Behavior; Testosterone
Publisher
Taylor and Francis Ltd
Type
journal article