Calcium Phosphate-Based Magnetic Nanoparticles as Thermoseeds for Cancer Hyperthermia Therapy
Date Issued
2009
Date
2009
Author(s)
Hou, Chun-han
Abstract
Hyperthermia therapy for cancer has drawn more and more attention these days. Many different types of magnetic particles have been developed for the purpose of hyperthermia cancer therapy. In the first part, we conducted an in vivo cancer hyperthermia study of the new magnetic hydroxyapatite nanoparticles (mHAP) on a mouse model. Only the mice which were injected with mHAP and had been treated inside the magnetic field showed dramatic reduction of tumor volume, in the 15-day observation period. No local recurrence was noted. Therefore, our new magnetic hydroxyapatite nanoparticles have demonstrated therapeutic effect in a mouse model with little toxicity. n the second part, a magnetic nanoparticle based on dicalcium phosphate dihydrate (DCPD) was formed by co-precipitation method. Addition of different concentrations of ferrous chloride to DCPD can alter its material properties. Various physical, chemical and magnetic tests of the magnetic DCPD nanoparticles (mDCPD) were performed, including x-ray diffraction (XRD), inductively coupled plasma-optical emission spectrometer (ICP-OES), superconducting quantum interference device (SQUID), and transmission electron microscopy (TEM). The heating efficiency of mDCPD in alternating magnetic field was proved to be suitable for hyperthermia. The results of cytotoxicity tests (WST-1 and LDH assay) showed no harmful effect. The mDCPD showed relative cancer-killing ability without damaging normal cells in vitro.
Subjects
magnetic nanoparticles
cancer
hyperthermia
hydroxyapatite
dicalcium phosphate dehydrate
SDGs
Type
thesis
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