Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients
Journal
European Journal of Endocrinology
Journal Volume
160
Journal Issue
5
Pages
777-783
Date Issued
2009
Author(s)
Chen H.-Y.
Chiu Y.-L.
Hsu S.-P.
Pai M.-F.
Peng Y.-S.
Kao T.-W.
Abstract
Background: Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. Methods: One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations. Results: Data from 63 women and 46 men aged 60±13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P<0.05). In multi-variable linear regression analysis, fetuin Awas independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2- and 4.4-fold higher incidence of truncal obesity (P=0.038) and hyper-triglyceridemia (P=0.015) independent of nutritional status and inflammation. Conclusion: Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients. ? 2009 European Society of Endocrinology.
Other Subjects
albumin; C reactive protein; calcium; creatine; fetuin A; hemoglobin; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; alpha2HS glycoprotein; lipoprotein; plasma protein; triacylglycerol; adult; aged; albumin blood level; article; body mass; cholesterol blood level; creatinine blood level; disease association; dyslipidemia; female; hemodialysis patient; human; inflammation; iron binding capacity; major clinical study; male; nutritional status; obesity; priority journal; protein blood level; triacylglycerol blood level; waist circumference; abdomen; blood; dyslipidemia; incidence; kidney failure; middle aged; obesity; pathology; physiology; renal replacement therapy; statistics; thorax; Abdomen; Aged; Blood Proteins; Dyslipidemias; Female; Humans; Incidence; Kidney Failure; Lipoproteins; Male; Middle Aged; Obesity; Renal Dialysis; Thorax; Triglycerides; Waist Circumference
Type
journal article