Higher plasma interleukin-18 levels associated with poor quality of sleep in peritoneal dialysis patients
Journal
Nephrology Dialysis Transplantation
Journal Volume
22
Journal Issue
12
Pages
3606-3609
Date Issued
2007
Author(s)
Abstract
Background. Sleep disorders are prevalent in patients with end-stage renal disease. Increasing evidence suggests that cytokines are involved in the regulation of sleep and wakefulness. The purpose of this study was to examine the relationship between quality of sleep and plasma interleukin-18 levels in peritoneal dialysis patients. Methods. Plasma interleukin-18 levels were determined by the enzyme-linked immunosorbent assay (ELISA) methodology in 57 peritoneal dialysis patients. Quality of sleep was measured using the Pittsburgh Sleep Quality Index. Demographic and routine laboratory data were recorded. Results. In our cohort, the poor sleepers had higher plasma interleukin-18 levels (559.16 ± 261.22 pg/ml vs 397.49 ± 191.81 pg/ml, P = 0.01). The plasma interleukin-18 level was positively correlated with the Pittsburgh Sleep Quality Index score (r = 0.286, P = 0.031), that is, there was a positive association between higher plasma interleukin-18 levels and poorer quality of sleep. Conclusion. This study demonstrates that interleukin-18 may be involved in sleep disorders in end-stage renal disease patients. Higher plasma interleukin-18 levels are associated with poorer quality of sleep in peritoneal dialysis patients. Whether a cause-and-effect relationship exists between interleukin-18 and quality of sleep deserves further study. ? The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Other Subjects
interleukin 18; adult; article; controlled study; demography; enzyme linked immunosorbent assay; female; human; major clinical study; male; peritoneal dialysis; Pittsburgh Sleep Quality Index; priority journal; protein blood level; scoring system; sleep; sleep pattern; Adult; Female; Humans; Interleukin-18; Male; Middle Aged; Peritoneal Dialysis; Quality of Life; Sleep
Type
journal article