Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds
Journal
Molecular Nutrition and Food Research
Journal Volume
58
Journal Issue
1
Pages
147-171
Date Issued
2014
Author(s)
Abstract
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and metabolic syndrome. NAFLD pathogenesis is complicated and involves oxidative stress, lipotoxicity, mitochondrial damage, insulin resistance, inflammation, and excessive dietary fat intake, which increase hepatic lipid influx and de novo lipogenesis and impair insulin signaling, thus promoting hepatic triglyceride accumulation and ultimately NAFLD. Overproduction of proinflammatory adipokines from adipose tissue also affects hepatic metabolic function. Current NAFLD therapies are limited; thus, much attention has been focused on identification of potential dietary substances from fruits, vegetables, and edible plants to provide a new strategy for NAFLD treatment. Dietary natural compounds, such as carotenoids, omega-3-PUFAs, flavonoids, isothiocyanates, terpenoids, curcumin, and resveratrol, act through a variety of mechanisms to prevent and improve NAFLD. Here, we summarize and briefly discuss the currently known targets and signaling pathways as well as the role of dietary natural compounds that interfere with NAFLD pathogenesis. ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
Chemoprevention; Dietary natural compounds; Nonalcoholic fatty liver disease
SDGs
Other Subjects
adipocytokine; carotenoid; curcumin; flavonol derivative; omega 3 fatty acid; polyphenol; resveratrol; stilbene derivative; animal; chemistry; chemoprophylaxis; Dietary natural compounds; fatty liver; human; insulin resistance; metabolism; nonalcoholic fatty liver; obesity; oxidative stress; pathophysiology; review; Chemoprevention; Dietary natural compounds; Nonalcoholic fatty liver disease; Adipokines; Animals; Carotenoids; Curcumin; Fatty Acids, Omega-3; Fatty Liver; Flavonols; Humans; Insulin Resistance; Obesity; Oxidative Stress; Polyphenols; Stilbenes
Type
journal article