Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity
Journal
Genes, Chromosomes and Cancer
Journal Volume
12
Journal Issue
3
Pages
161-164
Date Issued
1995
Author(s)
Abstract
Peripheral T?cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T?cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non?Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL. Copyright ? 1995 Wiley?Liss, Inc., A Wiley Company
SDGs
Other Subjects
t lymphocyte receptor; adult; article; cancer genetics; case report; chromosome 7q; chromosome analysis; clinical examination; human; isochromosome; liver tumor; male; priority journal; spleen tumor; t cell lymphoma; trisomy 8; Adult; Antigens, CD; Bone Marrow; Case Report; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Fatal Outcome; Genetic Markers; Human; Isochromosomes; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Male; Receptors, Antigen, T-Cell, gamma-delta; Spleen; Splenic Neoplasms; Support, Non-U.S. Gov't; Trisomy
Type
journal article