BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer
Journal
Medical Oncology
Journal Volume
33
Journal Issue
5
Date Issued
2016
Abstract
The prognostic implication of BRAF mutant colorectal cancer remains paradoxical. Records of BRAF mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of these patients were analyzed. Between 2005 and 2013, 428 colorectal cancer patients were enrolled in this study. The overall survival between BRAF mutant and wild-type patients with early-stage (stages I and II) colorectal cancer differed nonsignificantly (P?=?0.99). By contrast, in late-stage (stages III and IV) patients, the median overall survival of BRAF mutant patients (N?=?25) was significantly poorer than that of BRAF wild-type (N?=?207) patients (BRAF mutant: 21.3?months (95?% confidence interval [CI] 7.1–35.5); BRAF wild-type: 53.5?months (95?% CI 37.5–69.5), P?
SDGs
Other Subjects
B Raf kinase; bevacizumab; cetuximab; fluorouracil; folinic acid; irinotecan; oxaliplatin; B Raf kinase; BRAF protein, human; adjuvant therapy; adult; Article; cancer adjuvant therapy; cancer combination chemotherapy; cancer patient; cancer prognosis; cancer staging; cancer surgery; cancer survival; chemoembolization; clinical feature; colorectal cancer; controlled study; CpG island; female; genetic association; human; local therapy; major clinical study; male; medical record review; metastasis resection; methylator phenotype; microsatellite instability; monotherapy; multimodality cancer therapy; mutant; mutational analysis; overall survival; phenotype; priority journal; radiofrequency ablation; retrospective study; systemic therapy; tumor ablation; wild type; aged; colorectal tumor; DNA methylation; genetics; Kaplan Meier method; middle aged; mortality; multivariate analysis; mutation; pathology; prognosis; Aged; Colorectal Neoplasms; CpG Islands; DNA Methylation; Female; Humans; Kaplan-Meier Estimate; Male; Microsatellite Instability; Middle Aged; Multivariate Analysis; Mutation; Prognosis; Proto-Oncogene Proteins B-raf
Publisher
Humana Press Inc.
Type
journal article