Diffuse alveolar damage associated with ticlopidine use: A case report
Journal
Journal of the Formosan Medical Association
Journal Volume
102
Journal Issue
4
Pages
262-265
Date Issued
2003
Author(s)
Abstract
Ticlopidine-induced lung disease is rare. A 52-year-old man with acute myocardial infarction developed respiratory distress 2 days after receiving ticlopidine for coronary artery stenting. The dosage of ticlopidine was 500 mg orally followed by maintenance of 250 mg twice daily. Chest radiography revealed bilateral haziness predominantly over upper lung fields. He did not respond to treatment for suspected cardiogenic lung edema and mechanical ventilation was instituted. Open lung biopsy documented diffuse alveolar damage. After discontinuing ticlopidine and treatment with systemic corticosteroid, his pulmonary condition improved gradually. Within 2 weeks, the patient was successfully weaned from the ventilator. Although rare, diffuse alveolar damage is a potential side effect of ticlopidine treatment and should be included in the differential diagnoses of heart failure patients taking ticlopidine who respond poorly to optimal therapy.
SDGs
Other Subjects
acetylsalicylic acid; amiodarone; azathioprine; captopril; ciprofloxacin; clopidogrel; colchicine; corticosteroid derivative; cytotoxic agent; diuretic agent; dobutamine; gold salt; heparin; inotropic agent; magnesium oxide; methylprednisolone; penicillamine; salazosulfapyridine; streptokinase; ticlopidine; acute heart infarction; adult; allergic pneumonitis; article; artificial ventilation; blood dyscrasia; bronchiolitis; case report; coronary stent; diarrhea; differential diagnosis; drug efficacy; drug induced disease; drug safety; drug withdrawal; fibrosing alveolitis; heart failure; hepatitis; hospital infection; human; interstitial lung disease; lung edema; lung function test; lung nodule; lymphocytic colitis; maintenance drug dose; male; nausea; neutropenia; obstructive jaundice; open lung biopsy; rash; thorax radiography; transluminal coronary angioplasty; ventilator; vomiting; Humans; Lung Diseases; Male; Middle Aged; Platelet Aggregation Inhibitors; Pulmonary Alveoli; Ticlopidine
Type
journal article