Deformed wing virus infection affects the neurological function of Apis mellifera by altering extracellular adenosine signaling
Journal
Insect Biochemistry and Molecular Biology
Journal Volume
139
Date Issued
2021
Author(s)
Abstract
Deformed wing virus (DWV) infection is believed to be closely associated with colony losses of honeybee (Apis mellifera) due to reduced learning and memory of infected bees. The adenosine (Ado) pathway is important for maintaining immunity and memory function in animals, and it enhances antivirus responses by regulating carbohydrate metabolism in insects. Nevertheless, its effect on the memory of invertebrates is not yet clear. This study investigated how the Ado pathway regulates energy metabolism and memory in honeybees following DWV infection. Decreased Ado receptor (Ado-R) expression in the brain of infected bees resulted in a carbohydrate imbalance as well as impairments of glutamate-glutamine (Glu-Gln) cycle and long-term memory. Dietary supplementation with Ado not only increased the brain energy metabolism but also rescued long-term memory loss by upregulating the expression of memory-related genes. The present study demonstrated the regulation of the Ado pathway upon DWV infection and provides insights into the mechanisms underlying energy regulation and the neurological function of honeybees. ? 2021 Elsevier Ltd
Subjects
Adenosine
Deformed wing virus (DWV)
Honeybee (Apis mellifera)
Long-term memory
adenosine
animal
bee
energy metabolism
memory
metabolism
physiology
RNA virus
signal transduction
virology
Animals
Bees
Energy Metabolism
Memory
RNA Viruses
Signal Transduction
Type
journal article