微陣列基因體醫學核心實驗室II
Date Issued
2004
Date
2004
Author(s)
楊泮池
DOI
913112P002017Y
Abstract
Microarray technology is the central platform for functional genomics and translational
research in the post-genomic era. Our main goal is to establish an up-to-date microarray core
facility, dedicated to provide high quality microarrays, technical supports and services to researchers
in genomic medicine nationwide. Access to this high quality microarrays will allow our researchers
to be on the cutting edge of genetic research, focus on microarray-based gene expression profiling to
explore the pathogenic mechanism of human diseases. The microarray technology is particularly
important to clinical medicine in post-genomic era. It will provide high throughput and valuable
insights into differences in an individual’s disease as compared with constitutional mRNA
expression. The microarray information can provide tissue-specific disease signatures and
therefore, can improve disease diagnosis, disease classification, prognosis evaluation, identify
biomarkers, individualized patient treatment and improve treatment outcome.
Although the cDNA microarray is extremely powerful, the current application is still limited.
The major obstacles are its high cost and difficulty in maintaining good quality membrane and
experiment. The purpose of this project presented here is to establish the Core Lab and ESTs library
for high quality service of membrane-based cDNA microarray under the reasonable price. The core
facility will provide services including target labeling, microarray hybridization, colorimetric
detection, image digitization, and cluster analysis. In addition, the services of custom-made chips
including membrane- and glass-format microarray are also provided. According to the work
capacity, microarray core facility will open for the investigators of academic and research institution
participated in National Research Program of Genomic Medicine to apply.
The core facility has been established in National Taiwan University Hospital, National
Taiwan University College of Medicine for more than three years and manufactured more than
1,500 pieces of microarray membranes including human, mouse, and custom-made chips. Also, the
Core Lab offered related research consultation and education training to medical campus. National
Science Council supports our core facility last year to set up the “Microarray Core Facility for
Genomic Medicine”, which offers countrywide microarray services right away. The microarray core
facility has provided complete microarray services for dozens of institutions, including the
researchers of Taiwan University, Chung-Shan, Yang-Ming University, Chang-Geng University,
Chung-Shan Medical University, and so on, for more than 300 pieces of microarray membranes
including human, mouse, and custom-made chips. There are still hundreds of chips waiting for
preparation. We will provide services by the enrolled order and work capacity.
Subjects
Microarray
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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