Contribution of nuclear BCL10 expression to tumor progression and poor prognosis of advanced and/or metastatic pancreatic ductal adenocarcinoma by activating NF-κB-related signaling
Journal
Cancer cell international
Journal Volume
21
Journal Issue
1
Date Issued
2021-08-19
Author(s)
Abstract
We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. In this study, we assessed whether nuclear BCL10 translocation is clinically significant in advanced and metastatic pancreatic ductal adenocarcinoma (PDAC).
Subjects
BCL10; NF-κB; Pancreatic cancer; Prognosis
SDGs
Other Subjects
B cell lymphoma/leukemia 10; B-cell lymphoma 3 protein; cyclin A; cyclin B1; cyclin D1; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 4; cyclin E; DNA; gemcitabine; immunoglobulin enhancer binding protein; K ras protein; Myc protein; oxaliplatin; protein p21; protein p27; protein tyrosine phosphatase; short hairpin RNA; adult; advanced cancer; aged; animal experiment; animal model; Article; AsPC-1 cell line; BxPC-3 cell line; cancer prognosis; cancer recurrence; cell cycle; cell cycle progression; cell nucleus; cell viability; controlled study; cytoplasm; DNA binding; down regulation; drug cytotoxicity; drug potentiation; flank; G1 phase cell cycle checkpoint; G2 phase cell cycle checkpoint; gene silencing; genetic transfection; human; human cell; immunohistochemistry; inhibition kinetics; inoculation; M phase cell cycle checkpoint; major clinical study; male; metastasis potential; middle aged; mouse; NF kB signaling; nonhuman; overall survival; PANC-1 cell line; pancreas carcinoma; pancreatectomy; protein expression; protein transport; tumor growth; tumor xenograft; very elderly; wild type; young adult
Type
journal article