Cord blood transplantation for acute lymphoblastic leukemia in a pediatric patient
Journal
Journal of the Formosan Medical Association
Journal Volume
96
Journal Issue
3
Pages
205-208
Date Issued
1997
Author(s)
Abstract
The prognosis of Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) is poor. While umbilical cord blood transplantation has been used successfully for hematopoietic reconstitution, patients' size may be a limiting factor. We report a 11-year-old, 55-kg patient with Ph+ ALL, who received human leukocyte antigen-identical sibling donor cord blood transplantation (5.94 x 106 CD34+ cells) during the second ALL relapse. On days 25, 41, 75 and 103, successful engraftment was confirmed by cytogenetic studies. However, the leukemia relapsed on day 117 and the patient died on day 146 due to refractory ALL. In conclusion, based on the documented engraftment in our patient, we believe cord blood transplantation may be successfully employed in adolescent or possibly even adult patients.
Subjects
acute lymphoblastic leukemia; cord blood transplantation; Philadelphia chromosome
SDGs
Other Subjects
cyclophosphamide; epirubicin; methotrexate; prednisolone; vincristine; acute lymphoblastic leukemia; article; case report; cell transplantation; human; male; school child; umbilical cord blood; Blood Transfusion; Child; Fetal Blood; Graft vs Host Disease; Humans; Leukemia, Lymphocytic, Acute; Male
Type
journal article