Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma
Journal
BMC Veterinary Research
Journal Volume
7
Date Issued
2011
Author(s)
Abstract
Background: α-Enolase (ENO1) is a key glycolytic enzyme implicated in the development of many human cancers including breast cancer. Increased expression of ENO1 has recently been reported in estrogen (ER)-positive human breast cancer patients. The present study examined the expression of ENO1 and assessed its significance in canine mammary carcinoma.Results: Immunohistochemical staining was employed to investigate the expression of ENO1 in 82 cases of canine mammary tumor (32 benign tumors and 50 carcinomas). Quantification of immunohistochemistry was carried out using Quick score and the results showed cytoplasmic ENO1 overexpression in 9 of the 50 carcinomas (18%). Overexpression of ENO1 correlated significantly with shorter cause-specific survival (P = 0.019), but was not associated with ER positivity in canine mammary carcinoma.Conclusions: Our findings suggest that overexpression of ENO1 may be used as a prognostic marker for poor outcome in canine mammary carcinoma. ? 2011 Chu et al; licensee BioMed Central Ltd.
SDGs
Other Subjects
biological marker; enolase; animal; animal disease; article; chemistry; dog; dog disease; experimental neoplasm; female; gene expression regulation; immunoblotting; metabolism; mortality; udder; Animals; Biological Markers; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Immunoblotting; Mammary Glands, Animal; Mammary Neoplasms, Animal; Phosphopyruvate Hydratase
Type
journal article