Immunogenicity and safety of a quadrivalent inactivated influenza vaccine in healthy subjects aged 3 to 17 years old: A phase III, open label, single-arm study
Journal
Vaccine
Journal Volume
38
Journal Issue
22
Pages
3839-3846
Date Issued
2020
Author(s)
Abstract
Background: Quadrivalent influenza vaccines are particularly valuable during seasons in which a mismatch occurs between the predicted influenza B lineage for the trivalent influenza vaccine and the circulating strain. This study evaluated the immunogenicity and safety of a quadrivalent inactivated influenza vaccine AdimFlu-S manufactured in Taiwan for the 2016–2017 influenza season in healthy children. Methods: A total of 174 healthy children aged 3 to 17 years old were separated into 3 groups (Group A: 3–8 years old, vaccine na?ve; Group B: 3–8 years old, vaccine non-na?ve; Group C: 9–17 years old, any vaccine status). Sera was collected pre and post vaccination for each participant. A hemagglutination inhibition (HAI) assay was utilized to calculate geometric mean titer (GMT), seroprotection rate, and seroconversion rate. Results: All enrolled participants completed the study. For the four vaccine strains four weeks after the last vaccination, geometric mean titer ratios (GMTRs) were between 2.9 and 20.9, seroconversion rates were between 42.9% and 90.9%, and seroprotection rates were all above 96.4%. This achieved all immunogenicity endpoints and fulfilled the criteria of the European Medical Agency's Committee for Medicinal Products for Human Use (CHMP). No serious adverse events (AEs) were reported during the follow-up period of 6 months. Conclusion: This quadrivalent influenza vaccine is demonstrated to be well tolerated and displays robust immunogenicity for each influenza strain. This could potentially improve protection against the antigenically distinct B/Yamagata and B/Victoria lineages. ? 2020 Elsevier Ltd
SDGs
Other Subjects
influenza vaccine; inactivated vaccine; influenza vaccine; virus antibody; adolescent; Article; child; cohort analysis; drug safety; drug tolerability; female; follow up; hemagglutination inhibition test; human; influenza; male; multicenter study; phase 3 clinical trial; priority journal; prospective study; seroconversion; Taiwan; vaccination; vaccine immunogenicity; virus strain; blood; clinical trial; immunology; influenza; Influenza B virus; normal human; preschool child; Adolescent; Antibodies, Viral; Child; Child, Preschool; Healthy Volunteers; Hemagglutination Inhibition Tests; Humans; Immunogenicity, Vaccine; Influenza B virus; Influenza Vaccines; Influenza, Human; Taiwan; Vaccines, Inactivated
Publisher
Elsevier Ltd
Type
journal article