Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium
Journal
Planta medica
Journal Volume
66
Journal Issue
7
Date Issued
2000-10
Author(s)
Abstract
Further study on the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallylol (4), hydroxyepoxycollinin II (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.
Subjects
Alkaloids | Anti-HBV DNA replication | Antiplatelet aggregation activity | Coumarin | Furoquinolines | Root bark | Rutaceae | Terpenyl-coumarins | Zanthoxylum schinifolium
Other Subjects
8 methoxyanisocoumarin h; antithrombocytic agent; coumarin derivative; hydroxyepoxycollinin i; hydroxyepoxycollinin ii; hydroxyschininallylol; isoschinilenol; methylschinilenol; schininallylone; schinitrienin; unclassified drug; article; DNA replication; drug structure; phytochemistry; plant root; proton nuclear magnetic resonance; thrombocyte aggregation inhibition; Coumarins; Plant Roots; Platelet Aggregation Inhibitors; Rosales; Spectrum Analysis; Hepatitis B virus; Rutaceae; Zanthoxylum; Zanthoxylum schinifolium
Type
journal article