Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α
Journal
Blood Purification
Journal Volume
24
Journal Issue
2
Pages
174-179
Date Issued
2006
Author(s)
Hsu, Shih-Ping
Ho, Tai-I
Pai, Mei-Fen
Peng, Yu-Sen
Liu, Shing-Hwa
Abstract
Background/Aims: This study investigated changes of interleukin-18 (IL-18) levels before and after dialysis, and the possible association with other pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: Plasma IL-18 of healthy controls, and pre- and post-dialysis of uremic patients undergoing hemodialysis (HD) were evaluated by ELISA methodology. Results: Plasma IL-18 levels were significantly increased in patients with maintenance HD (p < 0.001) compared to its level in normal subjects. When compared to pre-dialysis levels, a significant increase in plasma IL-18 was measured at the end of HD (p = 0.032). There was a significant correlation among plasma IL-18, IL-6 and TNF-α levels in HD patients. Conclusion: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Pre-activation of immunologically active cells may contribute to the association between pre-dialysis IL-18 and post-dialysis IL-6 and TNF-α levels. Copyright ? 2006 S. Karger AG.
SDGs
Other Subjects
interleukin 18; interleukin 6; tumor necrosis factor alpha; adult; aged; article; blood analysis; clinical article; controlled study; enzyme linked immunosorbent assay; female; hemodialysis; human; kidney disease; male; priority journal; protein blood level; uremia; Aged; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-18; Interleukin-6; Male; Predictive Value of Tests; Renal Dialysis; Tumor Necrosis Factor-alpha; Uremia
Type
journal article