A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy
Journal
NANOMEDICINE
Author(s)
Abstract
To develop a micelle-type nanobubble decorated with fluorescein-5-isothiocyanate-conjugated transferrin, with encapsulation of paclitaxel (PTX@FT-NB) for lung cancer treatment. Materials & methods: PTX@FT-NBs were characterized to determine their physicochemical properties, structural stability and cytotoxicity. Lung cancer cell and mouse xenograft tumor models were used to evaluate the therapeutic effectiveness of PTX@FT-NB. Results: The PTX@FT-NBs not only showed selective targeting to lung cancer cells but also inhibited tumor growth significantly via paclitaxel release. Furthermore, paclitaxel-induced microtubule stabilization demonstrated the release of the drug from PTX@FT-NB in the targeted tumor cell both in vitro and in vivo. Conclusion: PTX@FT-NB has the potential as an anticancer nanocarrier against lung cancer cells because of its specific targeting and better drug delivery capacity. ? 2020 Future Medicine Ltd.. All rights reserved.
Subjects
lung cancer cells; microtubule stabilization; nanobubble; paclitaxel; transferrin
SDGs
Other Subjects
fluorescein isothiocyanate; paclitaxel; transferrin; antineoplastic agent; drug carrier; paclitaxel; phospholipid; animal experiment; animal model; animal tissue; Article; cancer cell; cancer therapy; controlled study; cytotoxicity; drug delivery system; drug efficacy; drug release; drug stability; drug structure; drug targeting; growth inhibition; human; human cell; lung cancer; mouse; nanoencapsulation; nonhuman; physical chemistry; priority journal; tumor xenograft; animal; drug delivery system; lung tumor; tumor cell line; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Lung Neoplasms; Mice; Paclitaxel; Phospholipids
Type
journal article