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  4. Methicillin-resistant Staphylococcus aureus omphalitis in neonates: An emerging threat?
 
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Methicillin-resistant Staphylococcus aureus omphalitis in neonates: An emerging threat?

Journal
Clinical Neonatology
Journal Volume
13
Journal Issue
2
Pages
64-67
Date Issued
2006
Author(s)
Chan F.-T.
CHUN-YI LU  
CHIEN-YI CHEN  
HUNG-CHIEH CHOU  
PO-NIEN TSAO  
WU-SHIUN HSIEH  
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247466538&partnerID=40&md5=8fa0731eaca5a6e099d1b59e3b881975
https://scholars.lib.ntu.edu.tw/handle/123456789/531047
Abstract
The incidence and severity of neonatal omphalitis has decreased after wide use of antiseptic delivery techniques. However, methicillin-resistant Staphylococcus aureus (MRSA) infectious disease is increasing in neonates. The significance of MRSA omphalitis has never been addressed in the literature. We retrospectively reviewed medical records of infants with the diagnosis of omphalitis in a single institution from April 1996 through May 2004. The bacteriologic profiles were analyzed. Gestational age, birth weight, mode of delivery, age at onset, clinical symptoms, and laboratory data were also collected for analysis. A total of 46 neonates were enrolled, including eight preterm infants. The incidence of omphalitis was 0.89 per 1000 live births. In full-term infants, 32 (84%) had umbilical cultures positive for bacterial infections. Among the full-term infants the predominant bacteria included Staphylococcus aureus (54%), with half of them being MRSA (29%), followed by Enterobacter cloacae (12%), Escherichia coli (10%), and Klebsiella spp (7%). In the preterm infants, five of the seven umbilical culture results showed MRSA. The MRSA group had longer hospitalization than the non-MRSA group (p=0.02). Initial treatment failure of omphalitis due to MRSA was found in 18% of the total neonatal omphalitis. One full-term infant died due to complications with necrotizing fasciitis and septic shock. Despite the low incidence of neonatal omphalitis, the threat of severe infection remains. Recognition of MRSA omphalitis is warranted due to the predominance of MRSA and its potential for lethal complications.
SDGs

[SDGs]SDG3

Other Subjects
ampicillin; gentamicin; imipenem; oxacillin; vancomycin; bacterium culture; birth weight; clinical article; clinical feature; combination chemotherapy; controlled study; delivery; disease severity; drug substitution; drug treatment failure; drug withdrawal; female; gestational age; human; incidence; infant; laboratory test; length of stay; live birth; male; medical record review; methicillin resistant Staphylococcus aureus; microbiological examination; monotherapy; necrotizing fasciitis; newborn infection; newborn mortality; omphalitis; onset age; prematurity; retrospective study; review; septic shock; Staphylococcus aureus; Staphylococcus infection
Type
review

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