Aortic mural thrombosis with bilateral renal infarction in a woman taking dienogest for adenomyosis: A case report and literature review.
Journal
Taiwanese journal of obstetrics & gynecology
Journal Volume
64
Journal Issue
5
Start Page
842
End Page
846
ISSN
1875-6263
Date Issued
2025-09
Author(s)
Abstract
Objective: We presented a rare case of aortic mural thrombosis with bilateral renal infarction in a woman taking dienogest for adenomyosis. The objective is to highlight the possible risk of thrombosis in woman with antiphospholipid syndrome taking progestin-only contraceptives for endometriosis. Case report: We presented a 48-year-old woman who has adenomyosis for years. After using dienogest for 1 month, she experienced severe abdominal pain and was diagnosed to have dienogest-induced aortic mural thrombosis and bilateral renal infarction. Successful treatment was achieved with the use of heparin followed by edoxaban. Intriguingly, the patient was diagnosed to have antiphospholipid syndrome 4 months later. The patient remained under regular follow-up for two years, during which no further thrombotic episodes were noted. Conclusion: Progestin-only contraceptives may be an acceptable choice for patients with adenomyosis and antiphospholipid syndrome, the risk of thrombosis should still be kept in mind.
Subjects
Adenomyosis
Antiphospholipid syndrome
Aortic mural thrombosis
Dienogest
SDGs
Type
journal article