Drawn-on-Skin Sensors from Fully Biocompatible Inks toward High-Quality Electrophysiology
Journal
Small (Weinheim an der Bergstrasse, Germany)
Journal Volume
18
Journal Issue
36
Date Issued
2022-09
Author(s)
Patel, Shubham
Ershad, Faheem
Chacon-Alberty, Lourdes
Wang, Yifan
Morales-Garza, Marco A
Haces-Garcia, Arturo
Jang, Seonmin
Gonzalez, Lei
Contreras, Luis
Agarwal, Aman
Rao, Zhoulyu
Liu, Grace
Efimov, Igor R
Zhang, Yu Shrike
Zhao, Min
Isseroff, Roslyn Rivkah
Karim, Alamgir
Elgalad, Abdelmotagaly
Zhu, Weihang
Wu, Xiaoyang
Yu, Cunjiang
Abstract
The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on-demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on-demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on-skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn-on-skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn-on-skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal-to-noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long-term, and accurate electrophysiological health monitoring.
Subjects
biocompatible inks; drawn-on-skin; electrophysiology; wearable bioelectronics
Publisher
WILEY-V C H VERLAG GMBH
Type
journal article