Fabrication of Multiresponsive Magnetic Nanocomposite Double-Network Hydrogels for Controlled Release Applications
Journal
Small
Journal Volume
17
Journal Issue
52
Date Issued
2021
Author(s)
Abstract
Nanocomposite double-network hydrogels (ncDN hydrogels) have been demonstrated as promising biomaterials to present several desired properties (e.g., high mechanical strength, stimuli-responsiveness, and local therapy) for biomedicine. Here, a new type of ncDN hydrogels featuring definable microstructures and properties as well as multistimuli responsiveness for controlled release applications is developed. Amine-functionalized iron oxide nanoparticles (IOPs_NH2) are used as nanoparticle cross-linkers to simultaneously connect the dual networks of gelatin (Gel) and polydextran aldehyde (PDA) through hydrogen bonding, electrostatic interactions, and dynamic imine bonds. The pH- and temperature-responsive Gel/PDA/IOP_NH2 ncDN hydrogels present a fast release profile of proteins at acidic pH and high temperature. Besides, IOP_NH2 also contributes the magnetic-responsiveness to the ncDN hydrogels, allowing the use of magnetic field to generate heat to facilitate the structural change of hydrogels and the subsequent applications. Taken together, a versatile ncDN hydrogel platform capable of multistimuli responsiveness and local heating for controlled release is developed for advanced biomedical applications. ? 2021 Wiley-VCH GmbH
Subjects
Hydrogels
Hydrogen bonds
Iron oxides
Medical applications
Nanomagnetics
Nanoparticles
Controlled release
Double network
Double-network hydrogels
Dynamic covalent bond
High mechanical strength
Magnetic nanocomposites
Multi-responsive
Nanocomposite hydrogels
Property
Stimuli responsiveness
Nanocomposites
biomaterial
nanocomposite
delayed release formulation
hydrogel
magnetism
Biocompatible Materials
Delayed-Action Preparations
Magnetic Phenomena
Type
journal article