Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons
Journal
Life Sciences
Journal Volume
54
Journal Issue
15
Pages
1119-1125
Date Issued
1994
Author(s)
Wang C.-R.
Chou H.-C.
Arvanov V.L.
Chen R.-C.
Chang Y.-C.
Chuang C.-Y.
Chen C.-Y.
Tsai M.-C.
Abstract
The effects of circulating anticardiolipin (ACL) antisera in lupus patients on the LP5 central neuron of snail were studied. Both GABA and glutamate increased a chloride conductance of the LP5 neuron. The ACL antisera decreased the GABA-elicited responses in a concentration dependent manner while it had no effect on glutamate-elicited responses. The ACL antisera affected neither the resting membrane current, nor the membrane conductivity of neuron. Antisera without the activity of anticardiolipin did not decrease the GABA-elicited responses. The seizure incidence of the patients with higher ACL antisera levels is also higher. It is concluded that ACL antisera inhibited the GABA ionophore receptor complex in a snail central neuron.
Type
journal article