Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland
Journal
Japanese Journal of Ophthalmology
Journal Volume
63
Journal Issue
4
Pages
344-351
Date Issued
2019
Author(s)
Abstract
Purpose: To survey adenoid cystic carcinoma of lacrimal glands in Asian population and investigate the predictability in prognosis following the 8th edition American Joint Committee on Cancer (AJCC) staging guideline. Study design: Retrospective study. Methods: The clinical entities and surgical outcomes of the patients who were histologically confirmed with a diagnosis of lacrimal adenoid cystic carcinoma in National Taiwan University Hospital between January 1995 and December 2015 were retrospectively reviewed. Results: Enrolled were 11 patients. The median follow-up was 7.2 years. Eight patients (72.7%) were diagnosed as T1 or T2 disease, and three patients (27.3%) were diagnosed as T3 or T4 disease according to the AJCC 8th edition guideline. Eye-sparing surgery with radiotherapy was performed in nine patients. Local recurrence was noted in six patients (54.5%) with median disease-free interval of 23.5 months. Six patients (54.5%) developed distant metastases, including lung, bone, and cranial invasions. Overall survival rate during the study period was 54.6%. Five-year overall survival was 81.8% and ten-year overall survival was 68.2%. The Log-rank test for overall survival and disease-free survival between patients with less than T3 disease (p=0.001) and patients with T3 or T4 disease (p=0.006) revealed significant differences. Conclusion: This study highlighted the aggressive nature of adenoid cystic carcinoma of lacrimal glands. Eye-sparing surgery with adjunctive radiotherapy may achieve relatively optimal disease control in diseases staged T1 or T2, but in advanced disease metastasis and mortality are usually inevitable. ? 2019, Japanese Ophthalmological Society.
SDGs
Other Subjects
adenoid cystic carcinoma; adult; advanced cancer; aged; Article; Asian; bone metastasis; cancer mortality; cancer prognosis; cancer radiotherapy; cancer recurrence; cancer staging; cancer survival; cataract; clinical article; clinical outcome; controlled study; diplopia; disease free interval; disease free survival; dry eye; eye surgery; eyelid erythema; female; follow up; glaucoma; human; lacrimal gland tumor; local recurrence free survival; lung metastasis; male; medical record review; middle aged; neuropathy; overall survival; postoperative period; practice guideline; priority journal; retinopathy; retrospective study; survival rate; tumor invasion; tumor volume; very elderly; young adult; adenoid cystic carcinoma; biopsy; cancer staging; epidemiology; eye surgery; eye tumor; lacrimal apparatus; lacrimal gland disease; mortality; pathology; procedures; prognosis; Taiwan; time factor; trends; Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Adenoid Cystic; Disease-Free Survival; Eye Neoplasms; Female; Follow-Up Studies; Humans; Lacrimal Apparatus; Lacrimal Apparatus Diseases; Male; Middle Aged; Neoplasm Staging; Ophthalmologic Surgical Procedures; Prognosis; Retrospective Studies; Survival Rate; Taiwan; Time Factors; Young Adult
Publisher
Springer Tokyo
Type
journal article