The effect of statins on cardiac allograft survival
Journal
Transplantation Proceedings
Journal Volume
46
Journal Issue
3
Pages
920-924
Date Issued
2014
Author(s)
Luo C.-M.
Tsao C.-I.
Abstract
Purpose In addition to having a lipid-lowering effect, statins also have an anti-inflammatory effect that may reduce allograft dysfunction by preventing cardiac allograft vasculopathy (CAV) and play an immunomodulatory role. We studied the effect of statins on cardiac allograft survival at the National Taiwan University Hospital (NTUH). Materials and Methods We retrospectively reviewed the patients undergoing heart transplantation at NTUH in the last 6 years. After transplantation, all patients received biochemical monitoring every month and echocardiographic examination regularly at NTUH. Protocol biopsy was performed in all except 18 pediatric patients. All patients received immunosuppressants, including tacrolimus or cyclosporine, everolimus or mycophenolate acid, and prednisolone. They were divided into statin and nonstatin groups according to whether or not a statin was taken. Results At NTUH, from 2007 to 2012, 168 heart transplantations were performed. The ages of the patients ranged from 6 to 74 years old with male predominance. The etiology was mainly dilated cardiomyopathy (52.4%) and ischemic cardiomyopathy (39.3%), including 7 retransplantations from severe CAV with heart failure. Twenty-three patients (17%) suffered from acute rejection. The overall 1-year actuarial survival rate was 86% ± 2% and the 5-year survival rate was 79% ± 3%. Seventy-eight patients (57.4%) took statins and the statin group has a better 5-year survival rate and freedom from cardiac death survival rate (P <.01). Conclusion Our study showed that the use of statins after transplantation was associated with better survival. ? 2014 by Elsevier Inc. All rights reserved.
SDGs
Other Subjects
atorvastatin; azathioprine; cyclosporin; everolimus; ezetimibe; flucastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; mycophenolic acid; prednisolone; rosuvastatin; steroid; tacrolimus; unclassified drug; hydroxymethylglutaryl coenzyme A reductase inhibitor; immunosuppressive agent; acute graft rejection; adult; aged; cardiac allograft vasculopathy; cardiac graft rejection; child; conference paper; congenital heart disease; congestive cardiomyopathy; controlled study; drug effect; drug megadose; echocardiography; female; graft survival; heart death; heart failure; heart graft; heart muscle biopsy; heart transplantation; human; human tissue; ischemic cardiomyopathy; major clinical study; male; myocarditis; overall survival; patient monitoring; priority journal; retransplantation; survival rate; survival time; Taiwan; university hospital; valvular heart disease; adolescent; heart transplantation; middle aged; retrospective study; young adult; Adolescent; Adult; Aged; Child; Female; Graft Survival; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Male; Middle Aged; Retrospective Studies; Survival Rate; Young Adult
Publisher
Elsevier USA
Type
conference paper