Effects of growth hormone and insulin-like growth factor 1 (IGF-1) on hepatic IGF-1-mRNA, plasma IGF-1 and nitrogen excretion in gastrectomized rats with liver cirrhosis
Journal
Clinical Nutrition
Journal Volume
15
Journal Issue
6
Pages
321-325
Date Issued
1996
Author(s)
Inaba T.
Saito H.
Fukushima R.
Hashiguchi Y.
Inoue T.
Fukatsu K.
Muto T.
Oka T.
Takenaka A.
Takahashi S.
Noguchi T.
Abstract
The growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis is impaired in liver cirrhosis. We determined the effects of GH and IGF-1 treatments in gastrectomized rats with thioacetamide-induced cirrhosis. GH did not increase hepatic IGF-1-mRNA, plasma IGF-1 or the tissue, i.e. gastrocnemius muscle IGF-1 level. IGF-1 administration increased plasma IGF-1 without increasing hepatic IGF-1-mRNA. GH and IGF-1 independently decreased postoperative urinary nitrogen excretion. We conclude that both GH and IGF-1 improve postoperative nitrogen metabolism. Furthermore, GH may exert its anabolic effects directly and/or via actions mediated by IGF-1 production, other than in the liver and in the skeletal muscle, in the setting of cirrhosis.
Publisher
Churchill Livingstone
Type
journal article