New Cytotoxic Constituents from the Formosan Soft Corals Clavularia viridis and Clavularia violacea
Resource
Journal of Natural Products 65 (11): 1535-1539
Journal
Journal of Natural Products
Journal Volume
65
Journal Issue
11
Pages
1535-1539
Date Issued
2002
Date
2002
Author(s)
Abstract
Three new cytotoxic prostanoids, claviridenone E-G (1-3), and three new cytotoxic steroids, stoloniferone E-G (4-6), were isolated from the methylene chloride solubles of the Formosan soft coral Clavularia viridis. A cytotoxic cembranoid, claviolide (7), was isolated from the methylene chloride solubles of the Formosan soft coral Clavularia violacea. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Other Subjects
cembranoid; claviolide; claviridenone e; claviridenone f; claviridenone g; dichloromethane; prostanoid; steroid; stoloniferone e; stoloniferone f; stoloniferone g; unclassified drug; antineoplastic activity; article; cancer cell culture; Clavularia violacea; clavularia viridis; coral; cytotoxicity; drug structure; in vitro study; nuclear magnetic resonance spectroscopy; structure analysis; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Lung Neoplasms; Methylene Chloride; Mice; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Prostaglandins; Steroids; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Clavularia; Clavularia viridis; Invertebrata
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
25.pdf
Size
106.56 KB
Format
Adobe PDF
Checksum
(MD5):32729220dd79969bdb4554492515d736