Clinical and histologic features of patients with biopsy-proven metabolic dysfunction-associated fatty liver disease
Journal
Gut and Liver
Journal Volume
15
Journal Issue
3
Pages
451-458
Date Issued
2021
Author(s)
Abstract
Background/Aims: Fatty liver disease is defined as a cluster of diseases with heterogeneous etiologies, and its definition continues to evolve. The novel conceptional criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) were proposed in 2020 to avoid the exclusion of a certain subpopulation, but their evaluations have been limited. We aimed to examine and compare the clinical as well as histologic features of MAFLD versus nonalcoholic fatty liver disease (NAFLD) in patients with biopsy-proven hepatic steatosis. Methods: From January 2009 to December 2019, 175 patients with histology-proven hepatic steatosis and 10 with cryptogenic cirrhosis who were treated at National Taiwan University Hospital, Taipei, Taiwan, were enrolled. Patients were classified into different groups according to the diagnostic criteria of MAFLD and NAFLD. The clinical and histologic features were then analyzed and compared. Results: In total, 76 patients (41.1%) were diagnosed with both MAFLD and NAFLD, 81 patients (43.8%) were diagnosed with MAFLD alone, nine patients (4.9%) were diagnosed with NAFLD alone, and 19 patients (10.3%) were diagnosed with neither. Those with MAFLD alone exhibited a higher degree of disease severity regarding histology and laboratory data than those with NAFLD alone. Advanced fibrosis was associated with the presences of hepatitis B virus infection and metabolic diseases. Conclusions: The novel diagnostic criteria for MAFLD include an additional 38.9% of patients with hepatic steatosis and can better help identify those with a high degree of disease severity for early intervention than can the previous NAFLD criteria. ? Gut and Liver.
SDGs
Other Subjects
adult; Article; clinical feature; comparative study; controlled study; disease severity; dyslipidemia; fatty liver; female; hepatitis B; histology; human; human tissue; hypertension; liver biopsy; liver cirrhosis; liver fibrosis; major clinical study; male; metabolic fatty liver; nonalcoholic fatty liver; retrospective study; Taiwan; biopsy; complication; Hepatitis B virus; nonalcoholic fatty liver; severity of illness index; Biopsy; Hepatitis B virus; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease; Severity of Illness Index
Publisher
Editorial Office of Gut and Liver
Type
journal article