Differential effects of progestins and estrogens on long control regions of human papillomavirus types 16 and 18
Journal
Biochemical and Biophysical Research Communications
Journal Volume
224
Journal Issue
3
Pages
651-659
Date Issued
1996
Author(s)
Abstract
We have studied effects of a series of progestins and estrogens on regulation of human papillomavirus (IBV) types 16 and 18 gene expression via long control region (LCR), using a transient expression assay which represented the episomal state of HPVs in precancerous lesions. Results showed that HPV gene expression induced by these steroid analogs were diverse. Gene expression via HPV16-LCR was upregulated 2-3 fold under treatment with 10-7 M estriol, 17β-estradiol, and several progestins including pregnenolone, 17α-hydroxy-progesterone, norethynodrel and cyproterone acetate. However, transcription via HPV18-LCR was not or weakly stimulated by these analogs. Our results can divide these analogs into HPV-enhancing and HPV-nonenhancing groups and accordingly impact the relative risk of individual oral contraceptive ingredient in cervical carcinogenesis.
SDGs
Other Subjects
17 hydroxypregnenolone; cyproterone acetate; estradiol; estriol; estrogen; gestagen; noretynodrel; oral contraceptive agent; pregnenolone; article; controlled study; DNA transcription; episome; gene expression regulation; human; human cell; nonhuman; precancer; priority journal; risk; uterine cervix cancer; virus genome; Wart virus
Type
journal article