The Ameliorative and Toxic Responses of Selenite in the Nematode Caenorhabditis elegans
Date Issued
2009
Date
2009
Author(s)
Li, Wen-Hsuan
Abstract
Selenium (Se) is an universal essential trace element for mammals which is important for many cell processes. As a constituent of selenoproteins, Se has structural and enzymic roles and it has been recognized as an antioxidant and chemopreventive agent in cancer. In this study, we use a model organism Caenorhabditis elegans to understand how Se affects the nematodes. To understand the effects of Se(IV) on C. elegans, we established the dose response relationship and found that the LC50 of Se was 2.785mM. Low level of Se (0.01 and 0.05 μM) accelerated the development rate and enhanced the resistances to the paralysis caused by the chemicals related to cholinergic signaling. However, at the addition of 20 μM, Se caused significant delays of development and serious decreases in fertility, body sizes and life span. It caused the worms more hypersensitive to the paralysis caused by aldicarb and levamisole. But at the supplementation of 0.01 μM, Se could provide resistance to the paralysis. Our results showed that Se has both beneficial (or protective) and adverse properties on development, fertility, growth, lifespan, and nervous system.
Subjects
Se
Caenorhabditis elegans
beneficial
adverse
SDGs
Type
thesis
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