Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families
Journal
American Journal of Medical Genetics - Neuropsychiatric Genetics
Journal Volume
105
Journal Issue
8
Pages
658-661
Date Issued
2001
Author(s)
Abstract
In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11-14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13-14 in an ethnically distinct Taiwanese sample. ? 2001 Wiley-Liss, Inc.
Subjects
Chromosome 15q; Linkage; Schizophrenia
SDGs
Other Subjects
microsatellite DNA; article; chromosome 15q; genetic linkage; genotype; human; major clinical study; marker gene; phenotype; priority journal; psychosis; schizoidism; schizophrenia; scoring system; Taiwan; Chromosomes, Human, Pair 15; DNA; Family; Family Health; Female; Genotype; Humans; Linkage (Genetics); Lod Score; Male; Microsatellite Repeats; Models, Genetic; Pedigree; Phenotype; Schizophrenia; Taiwan
Type
journal article