2021 advocacy statements for the role of99mTc-pyrophosphate scintigraphy in the diagnosis of transthyretin cardiac amyloidosis: A report of the Taiwan society of cardiology and the society of nuclear medicine of the republic of China
Journal
Acta Cardiologica Sinica
Journal Volume
37
Journal Issue
3
Pages
221–231
Date Issued
2021-01-01
Author(s)
Huang, Yih Hwen
Hou, Charles Jia Yin
Wang, Shan Ying
Tsai, Shih Chuan
Ho, Kung Chu
Lin, Ming Hsien
Tsao, Chin Ho
Chang, Chih Yung
Huang, Jin Long
Abstract
Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis,99mTc-labeled bone avid scintigraphy including99mTc-pyrophosphate (PYP) scintigraphy may be of diagnostic and prognostic importance. Various international guidelines support the non-biopsy diagnosis of ATTR-CM using99mTc-PYP scintigraphy, yet emphasize the gap in standardization of acquisition and imaging analysis protocols, as well as the appropriateness of its clinical use. Therefore, a joint expert consensus has been reached by the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China, to advocate for the application of99mTc-PYP scintigraphy in the diagnosis of ATTR-CM. This article aims to highlight the recommendations on image acquisition, qualitative and quantitative assessments of cardiac99mTc-PYP uptake, and diagnostic algorithms. We hope the implementation of these recommendations in Taiwan will facilitate the process and enhance the diagnostic rate of ATTR-CM.
Subjects
99m Tc-pyrophosphate (PYP) | Cardiac amyloidosis | Cardiomyopathy | Heart failure | Scintigraphy | Transthyretin
SDGs
Other Subjects
brain natriuretic peptide; cadmium; creatinine; gadolinium; pyrophosphate; pyrophosphate technetium tc 99m; quinine; technetium 99m; transthyretin; abdominal injury; accuracy; adult; AL amyloidosis; algorithm; amyloid neuropathy; angiocardiography; artery
Type
journal article