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  4. 2021 advocacy statements for the role of<sup>99m</sup>Tc-pyrophosphate scintigraphy in the diagnosis of transthyretin cardiac amyloidosis: A report of the Taiwan society of cardiology and the society of nuclear medicine of the republic of China
 
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2021 advocacy statements for the role of99mTc-pyrophosphate scintigraphy in the diagnosis of transthyretin cardiac amyloidosis: A report of the Taiwan society of cardiology and the society of nuclear medicine of the republic of China

Journal
Acta Cardiologica Sinica
Journal Volume
37
Journal Issue
3
Pages
221–231
Date Issued
2021-01-01
Author(s)
Huang, Yih Hwen
YEN-HUNG LIN  
RUOH-FANG YEN  
Hou, Charles Jia Yin
Wang, Shan Ying
Tsai, Shih Chuan
Ho, Kung Chu
Lin, Ming Hsien
Tsao, Chin Ho
Chang, Chih Yung
Huang, Jin Long
MEI-FANG CHENG  
YEN-WEN WU  
DOI
10.6515/ACS.202105_37(3).20210420A
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/587247
Abstract
Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis,99mTc-labeled bone avid scintigraphy including99mTc-pyrophosphate (PYP) scintigraphy may be of diagnostic and prognostic importance. Various international guidelines support the non-biopsy diagnosis of ATTR-CM using99mTc-PYP scintigraphy, yet emphasize the gap in standardization of acquisition and imaging analysis protocols, as well as the appropriateness of its clinical use. Therefore, a joint expert consensus has been reached by the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China, to advocate for the application of99mTc-PYP scintigraphy in the diagnosis of ATTR-CM. This article aims to highlight the recommendations on image acquisition, qualitative and quantitative assessments of cardiac99mTc-PYP uptake, and diagnostic algorithms. We hope the implementation of these recommendations in Taiwan will facilitate the process and enhance the diagnostic rate of ATTR-CM.
Subjects
99m Tc-pyrophosphate (PYP) | Cardiac amyloidosis | Cardiomyopathy | Heart failure | Scintigraphy | Transthyretin
SDGs

[SDGs]SDG3

Other Subjects
brain natriuretic peptide; cadmium; creatinine; gadolinium; pyrophosphate; pyrophosphate technetium tc 99m; quinine; technetium 99m; transthyretin; abdominal injury; accuracy; adult; AL amyloidosis; algorithm; amyloid neuropathy; angiocardiography; artery
Type
journal article

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