基因修補之基因體變異及喪失於臨床治療之運用
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
李章銘
DOI
932314B002254
Abstract
Variation in response to concurrent neoadjuvant chemoirradiation exists for the patients
of esophageal cancer. There are no reliable markers to predict the individual response for
such patients. A polymorphic CA repeat was found at the 5’-regulatory sequence in the
intron 1 of the EGFR gene, which influence the transcription activity of the gene. In this
study, we investigate whether this genetic polymorphism can modulate the response to
concurrent chemoirradiation for patients of esophageal cancer. We conducted a
prospective study including 121 patients with esophageal cancer who received concurrent
neoadjuvant chemoirradiation followed by esophagectomy in National Taiwan University
Hospital between 1996 and 2002. The EGFR genotype was determined by polymerase chain
reaction (PCR) amplification of leukocyte DNA obtained before surgery. The response
was classified as 1):good response which included patients with pathologically complete
remission or remained with microscopically residual tumor; and 2): poor response which
include grossly visible or progressively growing tumor after treatment. Results: There
were 47 (38.8 %) patients classified as good and 74 (61.2 %) as poor responders in this
study. We found the EGFR genotype were the single one factor influencing the response
to concurrent neoadjuvant chemoirradiation. As compared to patients with other genotypes,
those who with two long allele (> 19 CA) were more likely to poorly respond to treatment
(69.5% vs. 53.2%; OR (95% CI)= 2.03 (0.97-4.23); p=0.061). Conclusion: EGFR genetic
polymorphism might serve as a valuable predictor for the response to concurrent
chemoirradiation in patients of esophageal cancer, which help patients of esophageal cancer
of poor responders to chemoirradiation avoid unnecessary treatment before surgery.
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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