Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency
Journal
The New England journal of medicine
Journal Volume
390
Journal Issue
12
Date Issued
2024-03-21
Author(s)
Kashyap, Anuj
Salvator, Helene
Rosen, Lindsey B
Colby, Devon
Ardeshir-Larijani, Fatemeh
Loehrer, Patrick J
Ding, Li
Lugo Reyes, Saul O
Riminton, Sean
Ballman, Madison
Rocco, Joseph M
Marciano, Beatriz E
Freeman, Alexandra F
Browne, Sarah K
Hsu, Amy P
Zelazny, Adrian
Rajan, Arun
Sereti, Irini
Zerbe, Christa S
Lionakis, Michail S
Holland, Steven M
Abstract
Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common subunit with interleukin-23 (subunits p40 and p19). In a patient with disseminated Burkholderia gladioli infection, the identification of both anti-interleukin-23 and anti-interleukin-12 prompted further investigation.
Subjects
Allergy/Immunology | Autoimmune Disease | Bacterial Infections | Diagnostics | Fungal Infections | Immunodeficiency | Infectious Disease | Infectious Disease General | Inflammatory Disease | Rheumatology | Rheumatology General | T-Cells
Type
journal article