Reverse electromechanical modelling of diastolic dysfunction in spontaneous hypertensive rat after sacubitril/valsartan therapy
Journal
ESC heart failure
Journal Volume
7
Journal Issue
6
Pages
4040-4050
Date Issued
2020-12
Author(s)
Abstract
Hypertension is a significant risk for the development of left ventricular hypertrophy, diastolic dysfunction, followed by heart failure and sudden cardiac death. While therapy with sacubitril/valsartan (SV) reduces the risk of sudden cardiac death in patients with heart failure and systolic dysfunction, the effect on those with diastolic dysfunction remains unclear. We hypothesized that, in the animal model of hypertensive heart disease, treatment with SV reduces the susceptibility to ventricular arrhythmia.
Subjects
Cardiac bridging integrator-1
diastolic dysfunction
hypertensive heart disease
Sacubitril/valsartan
Small-conductance Ca2+-activated potassium channel type 2
Ventricular arrhythmogenesis
SDGs
Publisher
WILEY PERIODICALS, INC
Type
journal article