Glucose Conferred Irinotecan Chemoresistance through Divergent Actions of Pyruvate and ATP in Cell Death and Proliferation of Colorectal Cancer
Journal
Oncology
Journal Volume
100
Journal Issue
10
Pages
555
Date Issued
2022
Author(s)
Abstract
Altered glucose metabolism is associated with chemoresistance in colorectal cancer (CRC). This study aimed to illustrate the molecular mechanisms of glucose-mediated chemoresistance against irinotecan, a topoisomerase I inhibitor, focusing on the distinct roles of metabolites such as pyruvate and ATP in modulating cell death and proliferation.
Subjects
Cell cycle progression; Chemoresistance; Glucose metabolism; Programmed cell death; Spheroid cultures; Xenograft tumors
SDGs
Publisher
KARGER
Type
journal article