Cisplatin and Albumin-Based Gold-Cisplatin Nanoparticles Enhance Ablative Radiation Therapy-Induced Antitumor Immunity in Local and Distant Tumor Microenvironment
Journal
International journal of radiation oncology, biology, physics
Date Issued
2023-02-13
Author(s)
Yang, Shu-Jyuan
Pan, Chun-Kai
Lin, Li-Cheng
Tsai, Ching-Yi
Wang, Chung-Hao
Lin, Yu-Li
Abstract
Ablative radiation therapy (RT) is an important strategy to eliminate primary tumor and can potentially induce the abscopal effect. Human serum albumin nanoparticle (NP) was used for controlled release of cisplatin to decrease cisplatin's systemic toxicity, and gold (Au) was added to increase RT-induced immunogenic cell death and potentiate the abscopal antitumor immunity.
SDGs
Type
journal article