Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection
Journal
International Journal of Molecular Sciences
Journal Volume
23
Journal Issue
2
Date Issued
2022
Author(s)
Drobysh M
Ramanaviciene A
Viter R
Chen C.-F
Samukaite-Bubniene U
Ratautaite V
Ramanavicius A.
Abstract
Monitoring and tracking infection is required in order to reduce the spread of the corona-virus disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To achieve this goal, the development and deployment of quick, accurate, and sensitive diagnostic methods are necessary. The determination of the SARS-CoV-2 virus is performed by biosensing devices, which vary according to detection methods and the biomarkers which are inducing/providing an analytical signal. RNA hybridisation, antigen-antibody affinity interaction, and a variety of other biological reactions are commonly used to generate analytical signals that can be precisely detected using electrochemical, electrochemiluminescence, optical, and other methodologies and transducers. Electrochemical biosensors, in particular, correspond to the current trend of bioanalytical process acceleration and simplification. Immunosensors are based on the determination of antigen-antibody interaction, which on some occasions can be determined in a label-free mode with sufficient sensitivity. ? 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Antigen-antibody interaction
Bioelectrochemistry
Biosensors
COVID-19
Electrochemical immunosensors
Immobilisation of bio-molecules
Immune complex
Molecularly imprinted polymers (MIPs)
RNA analysis
SARS-CoV-2 virus
nanomaterial
chemistry
genetic procedures
human
isolation and purification
molecular diagnosis
procedures
serology
Biosensing Techniques
COVID-19 Testing
Humans
Molecular Diagnostic Techniques
Nanostructures
SARS-CoV-2
Serologic Tests
SDGs
Type
review