Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective
Journal
Reproductive biomedicine online
Journal Volume
23
Journal Issue
1
Pages
81
Date Issued
2011-07
Author(s)
Wong, Peng Cheang
Qiao, Jie
Ho, Clement
Ramaraju, Gottumukkala A
Wiweko, Budi
Takehara, Yuji
Nadkarni, Prashant V
Cheng, Li-Chang
HSIN-FU CHEN
Suwajanakorn, Somchai
Vuong, Thi Ngoc Lan
Abstract
LH and FSH have complementary functions in ensuring optimal oocyte maturation and ovulation. In women undergoing assisted reproduction technology protocols with gonadotrophin-releasing hormone analogues, LH and FSH concentrations are reduced. While FSH use in assisted reproduction technology is well established, there is no published consensus on the need for exogenous LH in Asian patients. Having reviewed the concept of the LH therapeutic window and differences between recombinant human LH (r-HLH) and human menopausal gonadotrophin, a consensus was reached on which patient subgroups may benefit from LH supplementation. Adjuvant r-HLH gives clinicians precise control over the dose of LH bioactivity administered to target the therapeutic window. The use of r-HLH is recommended in women with poor response in a previous cycle or suboptimal follicular progression in a current cycle by day 6-8 of stimulation. r-HLH should also be considered in women at risk of suboptimal response, specifically age > 35 years. Other risk markers that suggest the need for LH supplementation, which include baseline/day-6 serum LH and anti-Müllerian hormone concentrations, antral follicle count and LH polymorphisms require further research and verification. For measurement of LH response adequacy, the monitoring of follicular progression, oestradiol concentrations and endometrial thickness is recommended.
Subjects
Asia; GnRH agonist; IVF; ovarian stimulation; recombinant LH; FOLLICLE-STIMULATING-HORMONE; IN-VITRO FERTILIZATION; RECOMBINANT HUMAN LH; CONTROLLED OVARIAN HYPERSTIMULATION; AGONIST DOWN-REGULATION; NORMOGONADOTROPHIC WOMEN; SUBOPTIMAL RESPONSE; ANOVULATORY WOMEN; LONG PROTOCOL; LIVE BIRTH
SDGs
Publisher
ELSEVIER SCI LTD
Type
review