Synthesis and Applications of Photoluminescent Carbon Nanodots
Date Issued
2012
Date
2012
Author(s)
Hsu, Pin-Che
Abstract
This study aims to develop an environmentally benign method for the preparation of multifunctional carbon dots (C-dots). In chapter one, We have discussed a green synthetic approach for the preparation of photoluminescent C-dots from used coffee grounds. This is the first example of the large-scale hydrothermal synthesis of C-dots from used coffee grounds, which demonstrated two analytical applications [cell imaging and surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS)] showing its great practical potential. In chapter two, a highly water-soluble benign approach for the preparation of multifunctional C-dots from used green tea have been demonstrated. The inhibitory activity of C-dots is likely to be associated with catechins and their derivatives on the surfaces of C-dots. Unlike most of the C-dots preparation methods reported in the literature, the C-dots prepared from used green tea are highly effective and selective inhibitors for breast cancer cells (MCF-7 and MDA-MB-231), offering high practical potential for use in bioanalysis and medicine. In chapter three, a simple one-pot hydrothermal approach has been demonstrated for the preparation of highly water soluble and photoluminescent C-dots. We found that the compounds having amino and carboxylic acid groups are suitable for the preparation of high quantum yield C-dots (QY = 30.6 %). Therefore, this study not only revealed the development of simplified and convenient synthesis of C-dots, but also demonstrated large-scale preparation of high quantum yield C-dots. In addition, the as-prepared C-dots showed their great practical potentiality, which opens up further bioanalytical applications.
Subjects
C-dots
green tea
coffee
cell-imaging probe
cancer inhibitor
SALDI-MS matrix
SDGs
Type
thesis
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