Altered plasma acylcarnitine and amino acid profiles in type 2 diabetic kidney disease
Journal
Metabolomics
Journal Volume
12
Journal Issue
6
Pages
108
Date Issued
2016
Author(s)
Abstract
Introduction: Dysregulation of acylcarnitines (AcylCNs) and amino acids metabolism have implicated in abnormality of fatty acid oxidation in type 2 diabetes (T2D). However, it is not well known whether altered plasma AcylCN, and amino acid profiles are associated with albuminuria or diabetic nephropathy (DN) in T2D. Objective: The aim of this study was to elucidate alterations in plasma levels of AcylCNs and amino acids with respect to the T2D patients with various stages of albuminuria. Methods: We recruited 52 healthy subjects as control, and 156 T2D patients which were divided into 52 normoalbuminuria, 52 microalbuminuria, and 52 macroalbuminuria. Plasma 37 AcylCNs and 12 amino acids were analyzed by tandem mass spectrometry. Results: We found that T2D with normoalbuminuria and microalbuminuria had lower shot-, medium-, and long-chain AcylCNs, whereas T2D with macroalbuminuria had higher short-and medium-chain AcylCNs and lower long-chain AcylCNs than healthy subjects. Moreover, estimated glomerular filtration rate (eGFR) was a negative, independent and significant predictor of albumin to creatinine ratio (ACR) levels (β?=??0.376, P?
Subjects
Acylcarnitine; Amino acids; Diabetic nephropathy; Metabolomics; Type 2 diabetes
SDGs
Other Subjects
acylcarnitine; albumin; arginine; C reactive protein; carnitine derivative; cholesterol oxidase; citrulline; creatinine; glucose; glycine; hemoglobin A1c; high density lipoprotein cholesterol; isobutyrylcarnitine; isoleucine; leucine; low density lipoprotein cholesterol; methionine; ornithine; phenylalanine; triacylglycerol; tyrosine; unclassified drug; valine; adult; albuminuria; amino acid analysis; anthropometry; Article; blood pressure measurement; chemical analyzer; chemical reaction; colorimetry; controlled study; diabetic nephropathy; glomerulus filtration rate; human; lipid blood level; macroalbuminuria; major clinical study; microalbuminuria; non insulin dependent diabetes mellitus; tandem mass spectrometry; urinalysis
Publisher
Springer New York LLC
Type
journal article