Slow-release lanreotide in Graves' ophthalmopathy: A double-bline randomized, placebo-controlled clinical trial
Journal
Journal of Endocrinological Investigation
Journal Volume
29
Journal Issue
5
Pages
413-422
Date Issued
2006
Author(s)
Abstract
SS analogs are an attractive alternative in treating Graves' ophthalmopathy (GO). Most of the previous studies were uncontrolled and enrolled few patients. The present study was conducted as a larger scale, prospective, randomized controlled study to determine the effectiveness of a slow-release formulation of lanreotide in GO. Sixty patients with active GO received an im injection every two weeks of either lanreotide 30 mg or placebo for 12 weeks. They were then followed and further treated in the traditional way if necessary. The Clinical Activity Score (CAS) was the primary efficacy criterion. Proptosis, diplopia, corneal erosion or ulcer, visual acuity, extraocular muscle movement and intraocular pressure were also evaluated. At the end of the 12 weeks, the mean CAS was not significantly decreased in the lanreotide group compared to the placebo group. The overall mean difference of proptosis between these two groups also did not reach significance at 12 weeks. Only diplopia at downward gaze had significant improvement for the lanreotide-treated group vs placebo group (p=0.03). No differences were observed between the two groups compared to other outcome measures. During the 24-month follow-up after the clinical trial, 14 patients received eye surgery in the placebo group compared with 10 patients in the lanreotide group (p=0.29). Six patients received methylprednisolone pulse therapy in the placebo group and two patients in the lanreotide group (p=0.25). In conclusion, lanreotide treatment had no significant effects on GO compared with placebo. ? 2006, Editrice Kurtis.
SDGs
Other Subjects
angiopeptin; methylprednisolone; placebo; somatuline pr; abdominal distension; abdominal pain; adult; aged; article; clinical trial; controlled clinical trial; controlled study; cornea erosion; cornea ulcer; diarrhea; diplopia; dizziness; double blind procedure; drug dose regimen; drug efficacy; drug pulse therapy; drug safety; endocrine ophthalmopathy; exophthalmos; extraocular muscle; eye surgery; female; follow up; human; intraocular pressure; major clinical study; male; muscle contraction; nausea; outcome assessment; randomized controlled trial; scoring system; slow release formulation; treatment duration; visual acuity
Publisher
Editrice Kurtis s.r.l.
Type
journal article