三元體家庭資料連鎖不平衡檢定方法群之發展理論研究(3/3)
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
戴政
DOI
922118M002011
Abstract
Using the information of transmission-nontransmission of a parental marker
allele to the affected child in a case-parent triad family, currently there have been
many transmission linkage tests proposed for the inference of linkage between a
marker and a disease-susceptibility gene. Extensions of these methods to a variety of
problems such as multiple alleles, parent-missing, genetic heterogeneity and
quantitative trait loci were also widely studied. However, there still remain a couple of
problems that are worth studying: (1) There is not a comprehensive study that
investigates all the possible transmission linkage tests under the general disease
models. Therefore, it is not clear whether there still are, other than the existing ones,
some statistics that are valid for the test of linkage and how they perform. (2) It is
known that there are several nuisance parameters (linkage disequilibrium, marker and
disease allele frequencies, penetrances of disease genes) that can interfere with the
test of linkage, but it is not clear that how they jointly interfere with the test of linkage
under the general disease models. Here, we distinguish three types of
transmission-nontransmission data structure generated from the case-parent triad data
under the general disease models. For the three types of data structure we discover
twelve properties of symmetry or marginal homogeneity under the null hypothesis of
no linkage. Based on these properties, a systematic class of nine transmission linkage
tests under general disease models is developed. Three in it are new. The joint
interference structures of the studied nuisance parameters for the respective tests are
formulated. Simulations are conducted to examine the joint effect of the nuisance
parameters on the test of linkage under the general situations.
Subjects
inheritance mode
marginal homogeneity
symmetry
transmission
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
922118M002011.pdf
Size
100.47 KB
Format
Adobe PDF
Checksum
(MD5):07fb2de50a8cddf21a0c7cd6ce25a52e